Clinics and Research in Hepatology and Gastroenterology Volume 45, Issue 5 2021(original pdf)

Articles in this issue:

1.  

     Intraductal vacuum suction for high biliary stone retrieval during direct cholangioscopy

   Article 101600. Zimmer, Vincent.

   A 78-year-old female patient with a remote history of cholecystectomy and endoscopic papillotomy was referred for endoscopic retrograde cholangiopancreatography (ERCP) due to magnetic resonance cholangiopancreatography (MRCP)-confirmed distal chol…

   •  

2.  

     Pragmatic tools for the prediction and potential early diagnosis of hepatitis B virus-related hepatocellular carcinoma?

   Article 101722. Merle, Philippe.

   Hepatocellular carcinoma (HCC) is a major problem of public health, and chronic hepatitis B virus (HBV) infection ranks first as etiologic factor worldwide [1]. All along the natural history of chronic HBV infection, HCC is the main cause of death…

3.  

     Nothing but gastric schwannoma: A case of schwannoma mimicking stromal tumor

   Article 101630. Zhou, Ting-Ting, Lu, Yuan, and Liu, Wei.

   A 50-year-old woman was referred to our hospital with a 2-week history of epigastric pain. Esophagogastroduodenoscopy revealed a submucosal tumor in the middle part of the stomach ( Fig. 1A). Multiple biopsies were obtained. However, any submucosa…

   •  

4.   What are the effects of everolimus and basiliximab on Treg regulation and tolerance after liver transplantation?

   Article 101591. Le Moine, Alain.

   In their article “Influence of everolimus-based treatment on circulating regulatory T cells after liver transplantation: comparative study with tacrolimus-based therapy”, Barjon, Dahlqvist et al. report in a unique prospective randomized clinical …

   •  

5.  

     Japanese medlar bone in esophagus: Another set of eyes to better visualize!

   Article 101674. De Luca, Luca, and Di Berardino, Massimiliano.

   A 60-year old man was admitted to the emergency room department of local hospital in May 2020. He was in good health, with no medical history or home therapy. In the early morning, he had accidentally swallowed a Japanese medlar bone. The patient …

   •  

6.   Development and validation of a robust epithelial-mesenchymal transition (EMT)-related prognostic signature for hepatocellular carcinoma

   Article 101587. Chen, Shimin, and Zhao, Enfa.

   Highlights•The is the first study established a EMT-related genes prognostic signature in HCC. •Signature help to the understanding of the molecular mechanisms of HCC progression. •The EMT-related genes signature was an independent prognostic fact…

   •  

7.  

     An unusual cecal tumor with microsatellite instability

   Article 101653. Dong, Xinjie, Hu, Feng, Yu, Chengcheng, and Liu, Jixuan.

   An 82-year-old man presented with a 5-month history of altered bowel habit. His medical background included hypertension and type 2 diabetes and no personal or family history of any cancer. Abdominal computed tomography (CT) showed obvious thicken…

   •  

8.  

   Statins use and the prognosis of colorectal cancer: a meta-analysis  Download PDF

   Article 101588. Li, Liusheng, Cui, Ning, Hao, Tengteng, Zou, Jianhua, Jiao, Wu, Yi, Kangjun, and Yu, Wu.

   Highlights•Statins use might be significantly associated with lower overall mortality in CRC. •Statins use might be associated with lower cancer-specific mortality in CRC. •Statin use was a protective factor for CRC prognosis. AbstractBackgroundPr…

   •  

9.  

   A new model based on gamma-glutamyl transpeptidase to platelet ratio (GPR) predicts prognostic outcome after curative resection of solitary hepatocellular carcinoma  Download PDF

   Article 101509. Yang, Dongye, Wu, Hongliang, Nong, Wenxiong, Zheng, Min, Li, Angui, Wang, Yang, Li, Mu, Chen, Qian, Yuan, Shengguang, Yu, Junxiong, and Liao, Weijia.

   Highlights•Gamma-glutamyl transpeptidase to platelet ratio (GPR) may be a new prognostic indicator of hepatocellular carcinoma (HCC). •A novel predictive scoring model based on independent risk factors was established to identify different levels …

   •  

10.  

      Duodenum crescent sign due to gastroduodenal intussusception

    Article 101726. Yang, Qinglin, and Li, Jun.

    A 56-year-old man presented with abdominal distension for 4 days. Abdominal palpation was slightly painful in the epigastric area. The admitting laboratory evaluation revealed the following: white blood cell count 30.6 × 10 9/L; hemoglobin 59 g/L,…

    •  

11.  

      Duration from the first pale stool to portoenterostomy is prognostic in biliary atresia. Comparison with age at portoenterostomy

    Article 101584. Nakamura, Hiroki, Ara, Momoko, Koga, Hiroyuki, Miyano, Go, Okawada, Manabu, Doi, Takashi, Lane, Geoffrey J., Okazaki, Tadaharu, Urao, Masahiko, and Yamataka, Atsuyuki.

    Highlights•Age at portoenterostomy is crucial for prognosis according to almost all textbooks •Age at portoenterostomy remains prognostic in biliary atresia despite discrepancies •Duration from the first pale stool until portoenterostomy reflects …

    •  

12.  

      Combination of serum paraoxonase/arylesterase 1 and antithrombin-III is a promising non-invasion biomarker for discrimination of AFP-negative HCC versus liver cirrhosis patients

    Article 101583. Cao, Xinyi, Cao, Zhao, Ou, Chao, Zhang, Lei, Chen, Yanhua, Li, Yanqiu, Zhu, Bo, and Shu, Hong.

    Highlights•iTRAQ-based comparative proteomics analyses in AFP-negative HCC •Verification of aberrant expression of PON1 and ATIII •PON1 and ATIII as potential biomarkers to identify AFP-negative HCC versus LC SummaryObjectiveα-fetoprotein is often…

    •  

13.  

      Hydrochlorothiazide-induced hepatotoxicity: A rare case of DILI

    Article 101599. Malézieux, Emilie, Meunier, Lucy, Rivière, Benjamin, and Larrey, Dominique.

    AbstractThiazide diuretics are prescribed daily and rarely hepatotoxic. We report the case of 86-year-old woman who was admitted in hospital for jaundice after taking hydrochlorothiazide. All differential diagnoses have been eliminated. The liver …

    •  

14.  

      Inverted colonic diverticulum (ICD): report of two cases and literature review of a not that unusual endoscopic challenge

    Article 101711. Cocomazzi, Francesco, Carparelli, Sonia, Cubisino, Rossella, Giuliani, Arcangela Patrizia, Bossa, Fabrizio, Biscaglia, Giuseppe, Parente, Paola, Andriulli, Angelo, Perri, Francesco, and Gentile, Marco.

    AbstractInverted colonic diverticulum (ICD) is a rare intraluminal lesion occurring in about 0.7–1.7% of people, often endoscopically indistinguishable from polyps. Some unspecific endoscopic features may assist to distinguish polypoid ICD from tr…

    •  

15.   The role of miRNA125b in the progression of hepatocellular carcinoma

    Article 101712. Yang, Minghao, Wei, Sheng, Zhao, Huiyong, Zhou, Dachen, and Cui, Xiao.

    AbstractHepatocellular carcinoma (HCC) is one of the most common tumours worldwide, and identifying markers related to HCC is an important area of research. As a microRNA (miRNA), miRNA125b (miR-125b) plays an important role in the prediction and …

    •  

16.  

    Renal function in patients receiving streptozocin for locally advanced or metastatic digestive neuroendocrine tumours: results of the Streptotox-FFCD 0906 study  Download PDF

    Article 101572. Legoux, Jean-Louis, Lombard-Bohas, Catherine, Brixi, Hedia, Le Malicot, Karine, Lecomte, Thierry, Dahan, Laetitia, Ruszniewski, Philippe, Mahamat-Abakar, Abakar, Etienne, Pierre-Luc, Caroli-Bosc, François-Xavier, Dominguez, Sophie, Paule, Bernard, Terrebonne, Eric, Michel, Pierre, Lepage, Côme, and Choukroun, Gabriel.

    Highlights•This article on STZ-related nephrotoxicity describes one prospective and one retrospective cohort of patients with well-differentiated digestive neuroendocrine tumours. •The efficacy is on line with the previous series. •STZ toxicity wa…

    •  

17.  

    Increased sTREM-1 levels identify cirrhotic patients with bacterial infection and predict their 90-day mortality  Download PDF

    Article 101579. Tornai, David, Vitalis, Zsuzsanna, Jonas, Alexa, Janka, Tamas, Foldi, Ildiko, Tornai, Tamas, Sipeki, Nora, Csillag, Aniko, Balogh, Boglarka, Sumegi, Andrea, Foldesi, Roza, Papp, Maria, and Antal-Szalmas, Peter.

    Highlights•sTREM-1 is released from monocytes/macrophages and neutrophils during activation. •Presence of bacterial infection (BI) and ACLF increases sTREM-1 levels. •sTREM-1 and CRP identify BI among acute decompensated patients with similar accu…

    •  

18.  

      Thermal ablation of medium-sized hepatocellular carcinomas using intraoperative ultrasound fusion imaging: A propensity score-matched analysis

    Article 101581. Luo, Liping, He, Xuqi, Li, Kai, Long, Yinglin, Zeng, Qingjing, Tan, Lei, Zheng, Rongqin, and Xu, Erjiao.

    Highlights•Fusion imaging can accurately guide puncture and reduce thermal damage. •Sufficient ablation area for completely necrosis of the medium-sized HCCs. •Achieve good prognosis with lower LTP rate and good long-term survival. AbstractObjecti…

    •  

19.  

      Animal naming test for the assessment of minimal hepatic encephalopathy in Asian cirrhotic populations

    Article 101729. Qu, Yundong, Li, Tao, Lin, Chunlei, Liu, Feng, Wu, Shuo, Wang, Lei, and Ye, Qian.

    Highlights•S-ANT1 was an easily obtainable tool for the assessment of MHE. •A three-step screening strategy based on S-ANT1 and PHES was conducted. •The three-step screening strategy is conducive to the identification of MHE. AbstractBackground an…

    •  

20.  

      Predictive factors for hepatocellular carcinoma in chronic hepatitis B using structural equation modeling: a prospective cohort study

    Article 101713. Lam, Laurent, Fontaine, Hélène, Bourliere, Marc, Lusivika-Nzinga, Clovis, Dorival, Céline, Thabut, Dominique, Zoulim, Fabien, Habersetzer, François, Asselah, Tarik, Duclos-Vallee, Jean-Charles, Bronowicki, Jean-Pierre, Mathurin, Philippe, Decaens, Thomas, Ganne, Nathalie, Guyader, Dominique, Leroy, Vincent, Rosa, Isabelle, De Ledinghen, Victor, Cales, Paul, Causse, Xavier, Larrey, Dominique, Chazouilleres, Olivier, Gelu-Simeon, Moana, Loustaud-Ratti, Véronique, Metivier, Sophie, Alric, Laurent, Riachi, Ghassan, Gournay, Jérôme, Minello, Anne, Tran, Albert, Geist, Claire, Abergel, Armand, Raffi, François, D’Alteroche, Louis, Portal, Isabelle, Lapidus, Nathanaël, Pol, Stanislas, and Carrat, Fabrice.

    Highlights•We explored the pathways leading to hepatocellular carcinoma in hepatitis B disease. •The relationships between clinical characteristics and the cancer were analyzed. •Liver fibrosis has a key role in the occurrence of hepatocellular ca…

    •  

21.  

      Hepatitis B virus-associated hepatocellular carcinoma is still a matter of concern in the French Caribbean Island of Guadeloupe

    Article 101706. Benard, Julie, Lafrance, Marie-Josée, Gordien, Emmanuel, Amaral, Léonardo, Levrero, Massimo, Zoulim, Fabien, Saillard, Eric, and Gelu-Simeon, Moana.

    In the 1990’s, Guadeloupe, a French Caribbean Island, was classified as a territory intermediate prevalence for hepatitis B virus (HBV) with about 3% of hepatitis B surface antigen (HBsAg) carriage [1]. Such a prevalence may likely be related to t…

    •  

22.  

      ZFX promotes tumorigenesis and confers chemotherapy resistance in esophageal squamous cell carcinoma

    Article 101586. Wu, Jingjing, Zhou, Yu, Wang, Tao, Jiang, Chao, Gao, Yong, and Wei, Bin.

    Highlights•ZFX was highly expressed in ESCC tissues. •ZFX was positively associated with aggressive clinical features of ESCC. •ZFX predicted unfavorable prognosis in ESCC patients. •Knockdown of ZFX inhibited growth in the ESCC cells •ZFX conferr…

    •  

23.  

      Cellular communication network factor 1 (CCN1) knockdown exerts a protective effect for hepatic ischemia/reperfusion injury by deactivating the MEK/ERK pathway

    Article 101737. Liu, Huanqiu, Li, Ji, Jiang, Chengwei, Yuan, Tong, and Ma, Haichun.

    Highlights•CCN1 is upregulated in liver ischemia/reperfusion injury (IRI) and its knockdown prevents liver from the damage of IRI. •The activation of endoplasmic reticulum (ER) stress and MEK/ERK pathway induce apoptosis in hepatic IRI. •CCN1 knoc…

    •  

24.  

      Endoscopic Retrieval of a Proximally Migrated Pancreatic Stent through SpyGlass Pancreatoscopy

    Article 101707. Gomes, Catarina, Pinho, Rolando, Proença, Luísa, Afecto, Edgar, Correia, João, and Carvalho, João.

    Proximal plastic stent migration is an important adverse event of pancreatic duct (PD) stenting, occurring in around 5% of patients [1]. Usually, the endoscopic retrieval through different techniques and accessories, including forceps and snare gr…

    •  

25.  

      Isoflurane induces liver injury by modulating the expression of miR-125a-5p

    Article 101732. Li, Xingwei, Yao, Qun, Li, Ruijun, and Jin, Yanwu.

    Highlights•Isoflurane treatment increased the level of both ALT and AST in the serum of rats. •MiR-125a-5p was highly expressed in the liver tissues of rats treated with isoflurane. •Downregulation of miR-125a-5p significantly attenuated isofluran…

    •  

26.  

      Chemotherapy use in end-of-life digestive cancer patients: a retrospective AGEO observational study

    Article 101709. Lapeyre-Prost, Alexandra, Perkins, Geraldine, Vallee, Marie, Pozet, Astrid, Tougeron, David, Maillet, Marianne, Locher, Christophe, Dreanic, Johann, Legoux, Jean-Louis, Lièvre, Astrid, Lecaille, Cedric, Sabate, Jean-Marc, Mary, Florence, Bonnetain, Franck, Jaulmes-Bouillot, Hélène, Behal, Florence, Landi, Bruno, and Taieb, Julien.

    Highlights•Two-thirds of digestive cancer patients receive chemotherapy within the last 3 months of life. •Young patients and patients with aggressive disease receive more end-of-life chemotherapy. •Palliative care team intervention is associated …

    •  

27.  

      A study of leptin and its gene 2548 G/A Rs7799039 single-nucleotide polymorphisms in Egyptian children: A single-center experience

    Article 101724. Mohamed, Amal Ahmed, Ahmed, Hoda H., ElSadek, Sanaa M., Mohamed, Rasha S., El-Amir, Reham Y., Salah, Wafaa, Sultan, Eman, El-Hassib, Dalia M. Abd, and Fouad, Hanan M..

    Highlights•A comparable genotype’ distribution of leptin gene rs7799039 SNP observed in children with obesity and normal-weight. •High leptin was significantly associated with higher blood pressure, insulin resistance, and abnormal lipid profile. …

    •  

28.  

      Prognostic value of gamma-glutamyl transpeptidase in liver cirrhosis and hepatocellular cancer regardless of other parameters

    Article 101708. Ozcelik, Fatih.

    I read the article of Yang et al. with great interest [1]. In this study, it is reported that gamma-glutamyl transpeptidase to platelet ratio (GPR) can be used as a predictor for the postoperative prognosis and recurrence possibility of hepatocell…

    •  

29.  

      Proton pump inhibitors and the risk of colorectal cancer

    Article 101730. Kawada, Tomoyuki.

    Proton pump inhibitor (PPI) use induces hypergastrinemia and contributes to gut microbiota alteration, which may increase the risk of colorectal cancer (CRC). I read with great interest the article by Lei et al. [1], who conducted a prospective st…

    •  

30.  

      Quality improvement opportunities exist for Helicobacter pylori treatment and confirmatory testing

    Article 101720. Rodriguez, Natalie, Kennedy, Amanda G., Tompkins, Bradley J., VanOpdorp, Jocelyn, Heffley, Jason, and Ganguly, Eric.

    Highlights•Helicobacter pylori causes gastrointestinal infections such as peptic ulcer disease. •Global antibiotic resistance is increasing, reducing eradication rates. •Resistance rates vary worldwide and are unknown in Vermont. Helicobacter pylo…

31.  

      Measure grip strength, gait speed and quadriceps muscle in cirrhosis. Comment to “Frailty, sarcopenia and mortality in cirrhosis: What is the best assessment, how to interpret the data correctly and what interventions are possible?”

    Article 101727. Razaq, Sarah, Kara, Murat, and Özçakar, Levent.

    We have read the recent article by Lanthier et al. [1] with much interest. Our point of concern is two-fold; i.e., the lack of functional evaluation and the method of measuring muscle mass. First, sarcopenia is defined as age-related loss of both …

    •  

32.  

      High levels of interleukine-6 in ascites prevent ascites reinfusion during hemodialysis

    Article 101734. Halfon, Matthieu, Artru, Florent, Fraga, Montserrat, Comte, Denis, Alberio, Lorenzo, Brunet, Jean-Francois, Fakhouri, Fadi, and Kissling, Sebastien.

    Overall prognosis of patient with cirrhosis receiving maintenance hemodialysis (HD) is poor with a one-year mortality approaching 50% regardless of cirrhosis stage [1]. In decompensated cirrhosis, HD is even more challenging. In this condition, th…

    •  

33.  

      Peginterferon alfa-2b combined with tenofovir disoproxil fumarate induced high clinical cure rate in inactive chronic hepatitis B virus carriers

    Article 101723. Chen, Xue-Bing, Liu, Fei-Fei, Shu, Fu-Li, Liu, Jian-Ying, and Yang, Jia-Hong.

    Inactive hepatitis B s antigen (HBsAg) carriers (IHCs), which is characterized by the presence of serum hepatitis B e antigen (HBeAg) negative and antibodies to HBeAg (anti-HBe) positive, the quantification of HBsAg less than 1000 IU/ml, normal al…