Clinics and Research in Hepatology and Gastroenterology Volume 45, Issue 6 2021(original pdf)

Articles in this issue:

1.  

     Curious gastrointestinal nodules in a patient with known plasma cell disorder

   Article 101660. Stoleru, Gianna, Abutaleb, Ameer, and Urrunaga, Nathalie.

   A 46-year-old woman with multiple myeloma complicated by cardiac amyloidosis and resultant heart failure (HF) with ejection fraction (EF) of 65–70% presented with history of increasing anasarca. The patient was admitted and initiated on IV diuresi…

   •  

2.  

     Colon ischemia: A comprehensive review

   Article 101592. Maimone, Antonella, De Ceglie, Antonella, Siersema, Peter D., Baron, Todd H., and Conio, Massimo.

   Highlights•The clinical and endoscopic features of colon ischemia (CI) are non-specific. In most cases, CI is often considered to be “idiopathic”. •The majority of studies and the current guidelines do not provide about the need for endoscopic lon…

   •  

3.  

     Is targeting autophagy a promising lead to unveil the cloak of invisibility in pancreatic cancer?

   Article 101622. Cayron, C., Rigal, S., and Guillermet-Guibert, J..

   AbstractPancreatic ductal adenocarcinoma PDAC is considered as one of the less immunogenic solid tumor types. Pancreatic tumors are also known to present a high autophagy flux which supports tumor progression. Autophagy was recently described as a…

   •  

4.  

     A tricky upper GI bleeding: Duodenal intra-diverticular angioectasia treated by endoscopic band ligation

   Article 101680. Zimmer, Vincent, and Exner, Siegfried.

   A 78-year-old male patient on apixaban due to chronic atrial fibrillation presented with a two-day history of tarry stools. With a minimal hemoglobin level of 8.2 g/dL, the stable patient underwent upper endoscopy the following day after stopping …

   •  

5.  

     Zinc monotherapy for young patients with oligosymptomatic Wilson disease: A single center, retrospective study

   Article 101623. Hou, Haiman, Chen, Dingbang, Liu, Junxiu, Feng, Li, Zhang, Jiwei, Liang, Xiuling, Xu, Yuming, and Li, Xunhua.

   Highlights•The current study aimed to evaluate the long-term efficacy of zinc monotherapy in oligosymptomatic patients and to analyze the possible factors that may influence the outcome of zinc monotherapy. •We found that the baseline 24-h urine co…

   •  

6.  

     Hepatotoxicity of iodine-131 ablation for post-surgical differentiated thyroid cancer patients with hepatitis B virus infection

   Article 101631. Mo, Zhishuo, Lei, Ziying, Wang, Peipei, Wu, Zhebin, Yuan, Haijuan, Xie, Dongying, Wu, Zeqian, and Huang, Zenan.

   Highlights•Incidence of hepatotoxicity is higher in HBV group receiving radioiodine ablation treatment than non-HBV group. •HBV infection is a significant risk factor of hepatotoxicity for patients treated by radioiodine ablation. •Liver function …

   •  

7.  

     Novel albumin, bilirubin and platelet criteria for the exclusion of high-risk varices in compensated advanced chronic liver disease: A validation study

   Article 101598. Wong, Yu Jun, Kew, Guan Sen, Tan, Poh Seng, Chen, Zhaojin, Putera, Martin, Yip, Wenjun Alexander, Ang, Tiing Leong, Fock, Kwong Ming, Lee, Guan Huei, Hsiang, John, Huang, Daniel Q., Kwek, Andrew, Muthiah, Mark D., Kumar, Rahul, Tan, Malcolm, Tan, Jessica, Thurairajah, Prem Harichander, Teo, Eng Kiong, Tai, Bee Choo, and Lim, Seng Gee.

   Highlights•ABP (Albumin >40g/l, Bilirubin 114,000/μl) criteria is a novel, simple and validated criteria for the exclusion of high-risk varices (HRV). •Using simple biochemical parameters, ABP criteria is a useful tool that is easily scalable in r…

   •  

8.  

     NSAID-induced colonic diaphragm disease

   Article 101728. Zimmer, Vincent, and Emrich, Kai.

   A 64-year-old female patient with long-standing anti-cyclic citrullinated peptide (anti-CCP)-positive rheumatoid arthritis on leflunomide 20 mg per day presented for abdominal pain and diarrhoea passing up to 6 loose stools often coupled with bloo…

   •  

9.  

     Low levels of Lysosomal Acid Lipase (LAL) activity increases necroinflammation in adult patients with biopsy-proven metabolic associated fatty liver disease

   Article 101638. Thoen, Rutiane Ullmann, Longo, Larisse, Neto, Santiago Cassales, and Álvares-da-Silva, Mário Reis.

   Highlights•Metabolic associated fatty liver disease (MAFLD), a new terminology for non-alcoholic fatty liver disease (NAFLD). •Lysosomal acid lipase (LAL) is an enzyme that plays a pivotal role in lipid homeostasis. •Reduced LAL-activity is associ…

   •  

10.  

      Prognosis of patients undergoing salvage TIPS is still poor in the preemptive TIPS era

    Article 101593. Bouzbib, Charlotte, Cluzel, Philippe, Sultanik, Philippe, Bernard-Chabert, Brigitte, Massard, Julien, Benosman, Hedi, Mallet, Maxime, Tripon, Simona, Conti, Filomena, Thabut, Dominique, and Rudler, Marika.

    Highlights•Survival after salvage TIPS is still poor despite the preemptive TIPS policy and the use of PTFE-covered stents. •Prophylaxis of variceal bleeding, including the use of preemptive TIPS, is not well-conducted in real life. •Transplant-fr…

    •  

11.   Skeletal muscle loss during chemotherapy and its association with survival and systemic treatment toxicity in metastatic colorectal cancer: An AGEO prospective multicenter study

    Article 101603. Gallois, Claire, Bourillon, Camille, Auclin, Edouard, Artru, Pascal, Lièvre, Astrid, Lecomte, Thierry, Locher, Christophe, Marthey, Lysiane, Faroux, Roger, Pernot, Simon, Barret, Maximilien, and Taieb, Julien.

    Highlights•Pretherapeutic sarcopenia is not associated with poor outcomes in colorectal cancer. •The loss of skeletal muscle mass under treatment is highly prognostic. •The loss of skeletal muscle mass is associated with treatment-related toxiciti…

    •  

12.  

      Genetic polymorphism of fibroblast growth factor receptor 2 and trinucleotide repeat-containing 9 influence the susceptibility to HCV-induced hepatocellular carcinoma

    Article 101636. Al-Khaykanee(), Ahmed Mudher, Abdel-Rahman, Adel A-H., Essa, Abdallah, Gadallah, Abdel-Naser Abdel-Atty, Ali, Bushra Hameed, Al-Aqar, Afrodet Abdulrazaq, Badr, Eman A.E., and Shehab-Eldeen, Somaia.

    Highlights•Preventive measures of hepatocellular carcinoma (HCC) by recognizing its risk factors are crucial. •Genetic variations in genes that regulate pivotal cellular processes are potential candidates for HCC risk factors. •Single nucleotide p…

    •  

13.   Local treatment of pancreatic cancer metastases: A multicenter French study of the AGEO group

    Article 101607. Breton, Clémence, Meyer, Antoine, Malka, David, Matias, Margarida, De Baere, Thierry, Hammel, Pascal, Sa Cunha, Antonio, Lucchese, Angelica, Fuks, David, Coriat, Romain, Gallois, Claire, Touchefeu, Yann, Maillet, Marianne, Trouilloud, Isabelle, Rompteaux, Pierre, Carbonnel, Franck, and Soularue, Emilie.

    Highlights•In highly selected patients, local treatment of metastases from PDAC is associated with prolonged survival. •Factors associated with shorter OS were liver metastases, N2 status and synchronous metastases. •The rate of severe complicatio…

    •  

14.  

      Coenzyme Q10 deficiency in patients with hereditary hemochromatosis

    Article 101624. Martinefski, Manuela R., Yamasato, María F., Di Carlo, María B., Daruich, Jorge R., and Tripodi, Valeria P..

    Highlights•A decrease in plasma coenzyme Q10 (CoQ10) is described for the first time in patients with no treated hereditary hemochromatosis (HH). •The decrease in plasma CoQ10 was independent of the patient HFE genotype, cirrhosis occurrence, amin…

    •   

15.  

      Non-coding RNAs as biomarkers for hepatocellular carcinoma—A systematic review

    Article 101736. Zhao, Jinying, Wang, Yanhua, Su, Huahua, and Su, Lijia.

    AbstractHepatocellular carcinoma (HCC) is the sixth most common malignancy in the world and the fourth leading cause of cancer-related death, and its incidence is increasing globally. Despite significant advances in treatment strategies for HCC, t…

    •  

16.  

      Cytomegalovirus in pediatric inflammatory bowel disease patients with acute severe colitis

    Article 101625. Temtem, Tsega, Whitworth, John, Zhang, Jie, and Bagga, Bindiya.

    Highlights•There is increased prevalence of cytomegalovirus in pediatric inflammatory bowel disease patients with acute severe colitis. •Viral burden on histopathology is not predictive of response to therapy or long-term outcomes. •Lymphopenia is…

    •  

17.  

      The Ability of the Framingham Steatosis Index (FSI) to Predict Non-alcoholic Fatty Liver Disease (NAFLD): A Cohort Study

    Article 101567. Motamed, Nima, Nikkhah, Mehdi, Karbalaie Niya, Mohammad Hadi, khoonsari, Mahmoodreza, Perumal, Dhayaneethie, Ashrafi, G. Hossein, Faraji, Amir Hossein, Maadi, Mansooreh, Ajdarkosh, Hossein, Safarnezhad Tameshkel, Fahimeh, Moradi-Lakeh, Maziar, Miri, Seyyed Mohammad, Arsang-Jang, Shahram, and Zamani, Farhad.

    Highlights•FSI is a benefitial tool with strong ability to diagnisis of NAFLD. •New cases of NAFLD could be determined by using FSI tool which showed acceptable ability in this issue. •FSI ability is slightly better than that of BMI to diagnosis o…

    •  

18.   Adjuvant chemotherapy indications for stage I gastric cancer patients with negative lymph node

    Article 101634. Jin, Peng, Ji, Xiaoyan, Ma, Shuai, Kang, Wenzhe, Liu, Hao, Li, Yang, Ma, Fuhai, Hu, Haitao, Xiong, Jianping, and Tian, Yantao.

    Highlights•Whether adjuvant chemotherapy (AC) has a survival benefit for pathological stage Ⅰ (T1N0 and T2N0) gastric cancer (GC) patients with negative lymph node (N0) remains controversial. •Only T2 stage (HR 1.410; 95% CI 1.026−1.936), tumor si…

    •  

19.  

      Is it necessary to perform a morphological assessment for an esophageal motility disorder? A retrospective descriptive study

    Article 101633. Latrache, Sofya, Melchior, Chloe, Desprez, Charlotte, Sidali, Sabrina, Recton, Julien, Touchais, Olivier, van der Eecken, Elise, Wuestenberghs, Fabien, Charpentier, Cloe, Leroi, Anne Marie, and Gourcerol, Guillaume.

    Highlights•The literature about secondary forms of esophagus motor disorders at the exception of achalasia is limited. •In our study, 8.8% of esophagus motor disorder were identified as secondary thanks to CT-scan and/or endoscopic ultrasound, of …

    •  

20.  

      Trimetazidine alone or in combination with gemcitabine and/or abraxane decreased cell viability, migration and ATP levels and induced apoptosis of human pancreatic cells

    Article 101632. Atlı Şekeroğlu, Zülal, Şekeroğlu, Vedat, Işık, Sevil, and Aydın, Birsen.

    Highlights•TMZ reduced the cell viability at higher concentrations. •Lower cell viability values were found in cells treated with TMZ + GEM, TMZ + ABX. •The combined treatment of TMZ with ABX and/or GEM increased the apoptosis rates. •TMZ alone or…

    •  

21.  

      A guide for assessing the clinical relevance of findings in small bowel capsule endoscopy: analysis of 8064 answers of international experts to an illustrated script questionnaire

    Article 101637. Leenhardt, R., Koulaouzidis, A., McNamara, D., Keuchel, M., Sidhu, R., McAlindon, M.E., Saurin, J.C., Eliakim, R., Fernandez-Urien Sainz, I., Plevris, J.N., Rahmi, G., Rondonotti, E., Rosa, B., Spada, C., Toth, E., Houdeville, C., Li, C., Robaszkiewicz, M., Marteau, P., and Dray, X..

    Highlights•Small bowel capsule endoscopy findings car be categorize as of low (P0) / intermediate (P1) / high (P2) relevance, but this classification is currently based on a low level of knowledge. •The answers of 14 small bowel capsule endoscopy …

    •  

22.  

      Prospective evaluation of third-generation small bowel capsule endoscopy videos by independent readers demonstrates poor reproducibility of cleanliness classifications

    Article 101612. Dray, Xavier, Houist, Guy, Le Mouel, Jean-Philippe, Saurin, Jean-Christophe, Vanbiervliet, Geoffroy, Leandri, Chloé, Rahmi, Gabriel, Duburque, Clotilde, Kirchgesner, Julien, Leenhardt, Romain, and Cholet, Franck.

    Highlights•The main difficulty in comparing the different preparations is the lack of a reliable and reproducible tool that can assess SB cleanliness quality. •Three scores (quantitative index, qualitative evaluation, and overall adequacy assessme…

    •  

23.  

      Vena Cava and Pancreatic head En Bloc Resection for an Invasive Inferior Vena Cava Leiomyosarcoma in a Liver Transplant Patient

    Article 101609. Pitombo, Marcos Bettini, Goumard, Claire, Lim, Chetana, Sancio, João Bernardo, Mazzola, Alessandra, Prat, Frédéric, Vaillant, Jean-Christophe, Conti, Filomena, and Perdigao, Fabiano.

    AbstractBackgroundDe novo neoplasms are one of the major causes of death in patients after the first year of liver transplantation. The occurrence of sarcomas is extremely rare and the survival is often poor. However, early diagnosis and radical s…

    •  

24.  

      A novel mutation of PCSK1 responsible for PC1/3 deficiency in two siblings

    Article 101640. Duclaux-Loras, Rémi, Bourgeois, Patrice, Lavrut, Pierre-Marie, Charbit-Henrion, Fabienne, Bonniaud-Blot, Pauline, Maudinas, Raphael, Bournez, Marie, Faure, Mathias, Cerf-Bensussan, Nadine, Lachaux, Alain, Peretti, Noel, and Fabre, Alexandre.

    AbstractProprotein convertase 1 ( PCSK1, PC1/3) deficiency is an uncommon cause of neonatal malabsorptive diarrhoea associated with endocrinopathies that are due to the disrupted processing of a large number of prohormones, including proinsulin. T…

    •  

25.  

      Percutaneous ablation for locally advanced hepatocellular carcinoma with tumor portal invasion

    Article 101731. Blaise, Lorraine, Pereira, Helena, Vilgrain, Valérie, Sutter, Olivier, Gigante, Elia, Walter, Aurélie, Ganne-Carrié, Nathalie, Nahon, Pierre, Bouattour, Mohamed, Dioguardi Burgio, Marco, Grando, Véronique, Nkontchou, Gisèle, Seror, Olivier, and Nault, Jean-Charles.

    Highlights•Percutaneous ablation was compared to sorafenib or radioembolization in patients with HCC and portal vein invasion. •Overall survival (16.4 months in ablation group vs 14 months in the control group) was similar between the treatments. …

    •  

26.  

      Elevated preoperative CA125 levels predicts poor prognosis of hilar cholangiocarcinoma receiving radical surgery

    Article 101695. Xu, Ze-Liang, Ou, Yan-Jiao, Dai, Hai-Su, Wan, Kun, Bie, Ping, Chen, Zhi-Yu, Zhang, Lei-Da, and Zhang, Cheng-Cheng.

    Highlights•Hilar cholangiocarcinoma is a challenging disease for hepatobiliary surgeons. •There is still no good tumor marker to predict the prognosis of HCCA. •CA125 can be used for predicting long-term prognosis after radical surgery for HCCA. •…

    •  

27.  

      TSHZ3 functions as a tumor suppressor by DNA methylation in colorectal cancer

    Article 101725. Zhou, Youxin, Wang, Sentai, Yin, Xuequn, Gao, Guanzhuang, Wang, Qiang, Zhi, Qiaoming, Han, Ye, and Kuang, Yuting.

    Highlights•TSHZ3 is significantly down-regulated in CRC tissues, and patients with low TSHZ3 levels have a poorer 5-year overall survival rate. •Aberrant methylation of TSHZ3 promoter is an important regulator of TSHZ3 expression in CRC clinical s…

    •  

28.  

      Surgical rather than endoscopic resection of early-stage colorectal cancers promotes excessive imaging surveillance

    Article 101735. Bordet, Martin, Bretagne, Jean-François, Piette, Christine, Rousseau, Chloé, Grainville, Thomas, Cosson, Mathilde, and Lièvre, Astrid.

    Highlights•Little is known about the use of imaging surveillance after curative resection of early-stage colorectal cancer. •Imaging surveillance was analyzed in a cohort of 450 patients with screening-detected stage 0 or stage 1 colorectal cancer…